The project aims at producing on a large scale, by encapsulation, hepato-cholangiocyte organoids derived from human pluripotent stem cells in order todeliver a 3D model as close as possible to the human liver.
The goals of this project are to build an external bioartificial liver, a liver-on-chip as well as a bioengineered liver. In the present project, bioconstruction of the liver will be performed by the assembly of building blocks –liver organoids, vascular networks and biliary networks- built separately and then integrated into a scaffold.