Le projet vise à produire à grande échelle, par encapsulation, des organoïdes hépato-cholangiocytaires dérivés de cellules souches pluripotentes humaines afin d’établir un modèle 3D au plus proche du foie humain.
The goals of this project are to build an external bioartificial liver, a liver-on-chip as well as a bioengineered liver. In the present project, bioconstruction of the liver will be performed by the assembly of building blocks –liver organoids, vascular networks and biliary networks- built separately and then integrated into a scaffold.