Publications au titre du projet iLite (ANR-16-RHUS-0005) dont l’aide est financée par le programme d’Investissements d’Avenir lancé par l’État et mis en œuvre par l’ANR.
Eléanor Luce, Antonietta Messina, Jean-Charles Duclos-Vallée, Anne Dubart-Kupperschmitt
Advanced techniques and awaited clinical applications for human pluripotent stem cell differentiation into hepatocytes
Hepatology - 2021 Jan 8 - doi: 10.1002/hep.31705
Mathieu Danoy, Yannick Tauran, Stéphane Poulain, Hiroshi Arakawa, Daiki Mori, Karin Araya, Sachi Kato, Taketomo Kido, Hiroyuki Kusuhara, Yukio Kato, Atsushi Miyajima, Charles Plessy, Yasuyuki Sakai, Eric Leclerc∗
Analysis of hiPSCs differentiation toward hepatocyte-like cells upon extended exposition to oncostatin.
Differentiation - Accepted 11 May 2020 - https://doi.org/10.1016/j.diff.2020.05.006
Yannick Tauran, Stephane Poulain, Myriam Lereau-Bernier, Mathieu Danoy, Marie Shinohara, Bertrand-David Segard, Sachi Kato, Taketomo Kido, Atsushi Miyajima, Yasuyuki Sakai, Charles Plessy and Eric Leclerc
Analysis of the transcription factors and their regulatory roles during a step-by-step differentiation of induced pluripotent stem cells into hepatocyte-like cells.
Molecular Omics - Accepted 30th September 2019 - DOI: 10.1039/c9mo00122k
Legallais C, Kim D, Mihaila SM, Mihajlovic M, Figliuzzi M, Bonandrini B, Salerno S, Yousef Yengej FA, Rookmaaker MB, Sanchez Romero N, Sainz-Arnal P, Pereira U, Pasqua M, Gerritsen KGF, Verhaar MC, Remuzzi A, Baptista PM, De Bartolo L, Masereeuw R, Stamatialis D.
Bioengineering Organs for Blood Detoxification.
Adv Healthc Mater. 2018 Sep 19:e1800430. doi:10.1002/adhm.201800430.
Anette Funfak, Latifa Bouzhir, Emilie Gontran, Nicolas Minier, PascaleDupuis-Williams*† andSamyGobaa*†
Biophysical Control of Bile Duct Epithelial Morphogenesis in Natural and Synthetic Scaffold.
Front. Bioeng. Biotechnol. 7:417. doi: 10.3389/fbioe.2019.00417
Teresa Simon-Yarza⁎, Marie-Noëlle Labour, Rachida Aid, Didier Letourneur.
Channeled polysaccharide-based hydrogel reveals influence of curvature to guide endothelial cell arrangement in vessel-like structures.
Materials Science and Engineering - Accepted 5 August 2020 - https://doi.org/10.1016/j.msec.2020.111369
Laurent J, Blin G, Chatelain F, Vanneaux V, Fuchs A, Larghero J*, Thery M*.
Convergence of microengineering and cellular self-organization towards functional tissue manufacturing.
Nature Biomedical Engineering 2017 Dec;1:939–956. (* co- corresponding)
Amal Essaouiba, Teru Okitsu, Rie Kinoshita, Rachid Jellali, Marie Shinohara, Mathieu Danoy, Cécile Legallais, Yasuyuki Sakai, Eric Leclerc*
Development of a pancreas-liver organ-on-chip coculture model for organ-to-organ interaction studies.
Biochemical Engineering Journal - Accepted 30 August 2020 - https://doi.org/10.1016/j.bej.2020.107783
Marie-Noëlle Labour, Camile Le Guilcher, Rachida Aid-Launais, Nour El Samad, Soraya Lanouar, Teresa Simon-Yarza and Didier Letourneur*
Development of 3D Hepatic Constructs Within Polysaccharide-Based Scaffolds withTunable Properties.
International Journal of Molecular Sciences - Accepted: 18 May 2020 - https://doi.org/10.3390/ijms21103644
Latifa Bouzhir, Emilie Gontran, Lorena Loarca, Mauricette Collado-Hilly, Pascale Dupuis-Williams
Generation and Quantitative Characterization of Functional and Polarized Biliary Epithelial Cysts.
Jove, Journal of Visualized Experiments - Date Published: 5/16/2020 - https://www.jove.com/video/61404 doi:10.3791/61404
Mattia Pasqua, Ulysse Pereira, Antonietta Messina, Claire de Lartigue, Pascale Vigneron, Anne Dubart-Kupperschmitt, and Cecile Legallais.
HepaRG Self-Assembled Spheroids in Alginate Beads Meet the Clinical Needs for Bioartificial Liver.
Published Online:12 Feb 2020 https://doi.org/10.1089/ten.tea.2019.0262 Tissue Engineering, Part A.
Satomi Matsumoto, Eric Leclerc, Toshiro Maekawa, Haruyuki Kinoshita, Marie Shinohara, Kikuo Komori, Yasuyuki Sakai, Teruo Fujii⁎
Integration of an oxygen sensor into a polydymethylsiloxane hepatic culture T device for two-dimensional gradient characterization.
Sensors and Actuators B: Chemical - Accepted 11 May 2018 - https://doi.org/10.1016/j.snb.2018.05.053
Mathieu Danoy, Stephane Poulain, Rachid Jelalli, Francoise Gilard, Sachi Kato, Charles Plessy, Taketomo Kido, Atsushi Miyajima, Yasuyuki Sakai, Eric Leclerc*
Integration of metabolomic and transcriptomic profiles of hiPSCs-derived hepatocytes in a microfluidic environment.
Biochemical Engineering Journal - Accepted 3 January 2020 - https://doi.org/10.1016/j.bej.2020.107490
Rachid Jellalia⁎, Stephane Poulain, Myriam Lereau Bernier, Françoise Gilard, Yannick Tauran, Sachi Kato, Mathieu Danoy, Bertrand David Segard, Taketomo Kido, Atsushi Miyajima, Charles Plessy, Yasuyuki Sakai, Eric Leclerc⁎⁎
Integration of metabolomic and transcriptomic profiling to compare two protocols of differentiation of human induced pluripotent stem cells into hepatocyte.
Process Biochemistry - Accepted 28 September 2019 - https://doi.org/10.1016/j.procbio.2019.09.034
Satomi Matsumoto, Astia R. Safitri, Mathieu Danoy, Toshiro Maekawa, Haruyuki Kinoshita, Marie Shinohara, Yasuyuki Sakai, Teruo Fujii, Eric Leclerc.
Investigation of the hepatic respiration and liver zonation on rat hepatocytes using an integrated oxygen biosensor in a microscale device.
Biotechnology Progress - Accepted: 15 May 2019 - https://doi.org/10.1002/btpr.2854
Paul Van Liedekerke, Johannes Neitsch, Tim Johann, Kevin Alessandri, Pierre Nassoy, Dirk Drasdo.
Quantitative agent- based modeling reveals mechanical stress response of growing tumor spheroids is predictable over various growth conditions and cell lines.
PLoS computational biology 15(3) e1006273, 2019A.
Paul Van Liedekerke, Johannes Neitsch, Tim Johann, Enrico Warmt, Ismael Gonzales Valverde, Steffen Grosser, Stefan Hoehme, Josef Kaes, Dirk Drasdo.
Quantifying the mechanics and growth of cells and tissues in 3D using high resolution computational models.
bioRxiv 2019B, pp470559 Biomechanics and Modeling in Mechanobiology
Amal Essaouiba, Teru Okitsu, Rachid Jellali∗∗, Marie Shinohara, Mathieu Danoy, Yannick Tauran, Cécile Legallais, Yasuyuki Sakai, Eric Leclerc∗
Microwell-based pancreas-on-chip model enhances genes expression and functionality of rat islets of Langerhans.
Molecular and Cellular Endocrinology - Accepted 3 June 2020 - https://doi.org/10.1016/j.mce.2020.110892
Xavier Guchet et Cécile Legallais.
Nanotechnologies et ingénierie du foie bioartificiel. Une autre idée de la « convergence technologique ».
Philosophia Scientiæ [En ligne], 23-1 | 2019, DOI : 10.4000/philosophiascientiae.1839
Eléanor Luce and Anne Dubart-Kupperschmitt *
Pluripotent stem cell-derivedcholangiocytes andcholangiocyte organoids.
Methods in Cell Biology, Volume 159, ISSN 0091-679X - https://doi.org/10.1016/bs.mcb.2020.03.011
Antonietta Messina , Eléanor Luce, Marwa Hussein and Anne Dubart-Kupperschmitt *
Pluripotent-Stem-Cell-Derived Hepatic Cells: Hepatocytes and Organoids for Liver Therapy and Regeneration.
Cells 2020, 9, 420 - Accepted: 10 February 2020 - doi:10.3390/cells9020420
Mattia Pasqua, Ulysse Pereira, Claire de Lartigue, Jonathan Nicolas, Pascale Vigneron, Quentin Dermigny and Cécile Legallais.
Preclinical characterization of alginate‐Poly‐L‐Lysine encapsulated HepaRG for extracorporeal liver supply.
Biotechnology and Bioengineering - First published: 30 September 2020 - https://doi.org/10.1002/bit.27583
Myriam Lereau Bernier, Stéphane Poulain⁎, Yannick Tauran, Mathieu Danoy, Marie Shinohara, Keiichi Kimura, Bertrand David Segard, Sachi Kato, Taketomo Kido, Atsushi Miyajima, Yasuyuki Sakai, Charles Plessy, Éric Leclerc⁎
Profiling of derived-hepatocyte progenitors from induced pluripotent stem cells using nanoCAGE promoter analysis.
Biochemical Engineering Journal - Accepted 2 November 2018 - https://doi.org/10.1016/j.bej.2018.11.001
Alejandra Vargas-Valderrama , Antonietta Messina , Maria Teresa Mitjavila-Garcia and Hind Guenou.
The endothelium, a key actor in organ development and hPSC-derived organoid vascularization
Journal of Biomedical Science (2020) 27:67 - https://doi.org/10.1186/s12929-020-00661-y
Mathieu Danoy, ‡ Stéphane Poulain, ‡ Yuta Koui, Yannick Tauran, Benedikt Scheidecker, Taketomo Kido, Atsushi Miyajima, Yasuyuki Sakai, Charles Plessy and Eric Leclerc *
Transcriptome profiling of hiPSC-derived LSECs with nanoCAGE.
Molecular Omics - Accepted 2nd January 2020 - DOI: 10.1039/c9mo00135b